Citrus Auraptene, a unique compound found in citrus fruits, activates PPAR and Increases Adiponectin Expression In Vitro and In Vivo.
Fruit’s been given a really bad rap. I mean really bad. I hear it all the time. Oh, you should limit your amount of fruit during a diet. It’s going to wreck your diet. High Fructose Corn Syrup is nasty, just nasty. But that’s like saying sunshine is bad for you because it causes cancer. Fruit itself (and I’m not talking juices here) has so many unique and powerful fat burning, cancer killing and health promoting properties that you’d be a fool for not including them, even in fairly large amounts, in your diet if fat loss and overall health is your goal.
But enough of the lecture, I’m just wanting to share this study that details the invivo and invitro results of Citrus Auraptene (a chemical found in citrus fruit) on PPAR alpha and gamma. In particular the increase of adiponectin could be very useful. For those who don’t know, adiponectin is a signalling hormone like leptin and insulin, that originates from fat cells and basically tells the body that everything is good, we’re well fed, it’s ok to burn some fat off, so and so forth. Fat people with metabolic syndrome have lowered adiponectin activity and are insensitive to leptin and insulin. Reverse these three things for a significant period of time and you will have a complete reversal of symptoms.
J Agric Food Chem. 2010 Aug 3. [Epub ahead of print]
Effects of Citrus Auraptene (7-Geranyloxycoumarin) on Hepatic Lipid Metabolism in Vitro and in Vivo.
Nagao K, Yamano N, Shirouchi B, Inoue N, Murakami S, Sasaki T, Yanagita T.
Laboratory of Nutrition Biochemistry, Department of Applied Biochemistry and Food Science, Saga University, Saga 840-8502, Japan.
Abstract
Recent reports have shown that citrus auraptene (7-geranyloxycoumarin) possesses valuable pharmacological properties, including anticarcinogenic, anti-inflammatory, antihelicobacter, antigenotoxic, and neuroprotective effects. In the present study, we investigated the effect of dietary auraptene on hepatic lipid metabolism both in vitro and in vivo. Results suggested that auraptene has the ability to normalize lipid abnormalities in HepG2 hepatocytes. After 4 weeks of auraptene feeding, abdominal white adipose tissue weight and hepatic triglyceride (TG) levels were dose-dependently lowered in Otsuka Long-Evans Tokushima fatty (OLETF) rats. The activities of carnitine palmitoyltransferase, a key enzyme in mitochondrial fatty acid beta-oxidation, and peroxisomal beta-oxidation were markedly and dose-dependently enhanced in OLETF rat livers by auraptene feeding. Additionally, hepatic expression of acyl-CoA oxidase, the initial enzyme of the peroxisomal beta-oxidation system, was significantly and dose-dependently enhanced by auraptene administration. These results suggest that auraptene administration alleviates obesity and hepatic TG accumulation in part through lipolysis enhancement in the livers of obese OLETF rats.
PMID: 20681532 [PubMed - as supplied by publisher]
