We’ve all heard that Resveratrol is the next miracle that will melt off the pounds and let us live until we’re 300. Scientific research is finally catching up with these claims and for the most part is in agreement.
Of course you won’t live as long as Yoda (and no I’m not a Star Wars Geek, just the first thought that came to mind when I think of old dudes) and it’s not going to melt off the fat without any effort on your part to make some changes to the stuff you put in your mouth. But taken together with a sense of revolution in your ways of thinking, moving and eating, this can be just the thing you need to get that edge that will help you undo the damage you’ve already done to your Adipostat, or the internal metabolic thermometer that determines what is a normal amount of fat to hold on to.
You see, there are genes that you switch on when you eat an excess of energy, especially carbohydrate. Some of these genes are inhibited, switched off, while others are turned on. Sirt1 is a gene that promotes longevity by mimicking the effects of caloric restriction. Rather, resveratrol possesses the unique ability to switch on this gene while it only normally is flipped on when one stops eating so damn much. The effects of Sirt1 are far-reaching and at the same time, too subtle for the marketing geniuses at multi-level health supplement companies. But what happens when you just cut out a sensible amount of sugar from your diet and then spark this gene’s activation with some Resveratrol (I highly reccomend a 98% extract because anything less can upset the stomach because of some other compounds found in most popular resveratrol supplements) is nothing short of amazing when you consider all other variables at play.
We talked a little about Sirt1 and that it’s beneficial to those looking to lose weight. Ppar-Gamma is a nasty bugger of a gene that flips on when you consume too much energy, especially carbohydrate. This is essentially the fat-cell making gene. Switch this baby on and your body will begin creating new fat cells to store all the triglycerides that are produced from all those potato chips you shoved in your mouth last year. Lo and behold, this study shows that Resveratrol not only activates positive genes but it also inhibits this gene that encourages fat buildup.
Now this doesn’t mean we have something that’s going to cheat the system. A car can only go so fast as the engine can push. But think of resveratrol as a fuel injection cleaner. Once you’ve made the decision to start cleaning up your diet, your results will come with more certainty and swiftness than without. But also know that genetic changes like the ones described here are a subtle and long term change. Consider Resveratrol to be a long-term solution to your lifelong bad habits.
Obes Surg. 2010 Sep 26. [Epub ahead of print]
Resveratrol Upregulated SIRT1, FOXO1, and Adiponectin and Downregulated PPARγ1-3 mRNA Expression in Human Visceral Adipocytes.
Departamento de Bioquímica, ICBS, UFRGS, Rua Ramiro Barcelos 2600 Anexo, 90035-003, Porto Alegre, RS, Brazil.
BACKGROUND: The SIRT1 enzyme is involved in adipose tissue (AT) lipolysis. FOXO1 is a protein that plays a significant role in regulating metabolism. Adiponectin is an adipokine, secreted by the AT, which has been considered to have an antiobesity function. PPARγ is one of the key actors in adipocytes differentiation. This study was undertaken to investigate whether resveratrol can regulate SIRT1, FOXO1, adiponectin, PPARγ1-3, and PPARβ/δ in human AT.
METHODS: The effects of resveratrol were analyzed in freshly isolated adipocytes prepared from visceral fat tissue samples obtained during bariatric surgery. Genes messenger ribonucleic acid (mRNA) levels were determined by qRT-PCR.
RESULTS: Ours results show that resveratrol modulates the studied genes, increasing SIRT1 (p = 0.021), FOXO1 (p = 0.001), and adiponectin (p = 0.025) mRNA expression and decreasing PPARγ1-3 (p = 0.003) mRNA in human visceral adipocytes.
CONCLUSIONS: Resveratrol, in vitro and at low concentration, modulates genes that are related to lipid metabolism, possibly preventing metabolic disease in human visceral adipose tissue (VAT).
PMID: 20872255 [PubMed - as supplied by publisher]