I go on and on about inflammation and how it leads to almost all modern disease. But what do I mean by this? What is this inflammation caused by?
A macrophage is a white blood cell whose job is to digest cellular junk and pathogens (like cold viruses or bacterial infections). We simply wouldn’t exist without the intervention of such crucial pieces of our immune system. But what happens when we start eating ourselves to death? Our body goes to work of course, trying to rid us of this garbage we keep shoving into our mouths, and subsequently, our cells. Essentially our own immune system begins to try and attack all the excess junk that builds up and when our immune system activates we are left with what is known as inflammation. In a way it’s almost the same kind of inflammation that occurs when you lay in the sun too long, our body goes to work trying to defeat what it thinks is an invader.
So what’s the result? This pervasive inflammation is like a crying baby. All other appropriate messages are drowned out by the screaming. Our cells are trying to tell our brain and our pancreas that they’ve had enough, but the brain can’t hear them because the baby’s cries drown out this essential information.
So this new year do your body, your immune system, a favor and stop making yourself “sick”.
J Clin Invest. 2010 Sep 27. pii: 44721. doi: 10.1172/JCI44721. [Epub ahead of print]
In obesity and weight loss, all roads lead to the mighty macrophage.
Obesity is associated with infiltration of white adipose tissue (WAT) by macrophages, which contributes to the development of insulin resistance. In this issue of the JCI, Kosteli and colleagues demonstrate that weight loss is unexpectedly also associated with rapid, albeit transient, recruitment of macrophages to WAT and that this appears to be related to lipolysis.
PMID: 20877005 [PubMed - as supplied by publisher]