Effects of Eucommia Leaf Extracts on Fat Loss, Thermogenesis and Appetite

Posted by admin on 30th August , 2010

Suppress Appetite and Increase Thermogenesis

A unique extract of Eucommia Ulmoides has been shown to increase thermogenesis and decrease parasympathetic nerves in the gut which leads to reduced appetite.

I normally wouldn’t go nuts about a hamster study, but this was pretty unique in that it wasn’t through the typical metabolic pathways most fat-reducers in rats usually produce results. Most rat and mice studies that show extremely promising fat-loss results are usually manipulating special metabolic parameters found only in mice and rats, not so much in humans. For instance brown adipose tissue is highly metabolically active. Anything that stimulates Brown Adipose Tissue is going to have a profound impact on fat loss and prevention of fat gain. Unfortunately, for humans, we don’t have but a tiny amount of brown adipose tissue so this phenomenon is almost entirely inconsequential to our own efforts.

But a few things made this study unique. One is that the thermogenesis was created by increasing nerve activity in BOTH white and brown adipose tissue (humans have plenty of white adipose tissue). Secondly there was an appetite suppression that came from parasympathetic nervous activity in the intestines. So this could be a good route of appetite suppression.

Eucommia Ulmoides, as I found out, has been used in traditional chinese medicine for years for lower back pain and to prevent miscarriage. If those effects seem odd it’s mostly because chinese medicine IS odd. I’m not here to argue its merits, but I find the whole TCM thing to be odd in general. Also, another interesting fact about Eucommia Ulmoides: Its leaves have latex inside them.

Neurosci Lett. 2010 Aug 2;479(3):181-6. Epub 2010 May 16.

Effects of Eucommia leaf extracts on autonomic nerves, body temperature, lipolysis, food intake, and body weight.

Horii Y, Tanida M, Shen J, Hirata T, Kawamura N, Wada A, Nagai K.

ANBAS Corporation, 4-12-17 Toyosaki, Kita-Ku, Osaka 531-0072, Japan. yhorii@anbas.co.jp

Abstract

Eucommia ulmoides Oliver leaf extracts (ELE) have been shown to exert a hypolipidemic effect in hamsters. Therefore, it was hypothesized that ELE might affect lipid metabolism via changes in autonomic nerve activities and causes changes in thermogenesis and body weight. We examined this hypothesis, and found that intraduodenal (ID) injection of ELE elevated epididymal white adipose tissue sympathetic nerve activity (WAT-SNA) and interscapular brown adipose tissue sympathetic nerve activity (BAT-SNA) in urethane-anesthetized rats and elevated the plasma concentration of free fatty acids (FFA) (a marker of lipolysis) and body temperature (BT) (a marker of thermogenesis) in conscious rats. Furthermore, it was observed that ID administration of ELE decreased gastric vagal nerve activity (GVNA) in urethane-anesthetized rats, and that ELE given as food reduced food intake, body and abdominal adipose tissue weights and decreased plasma triglyceride level. These findings suggest that ELE stimulates lipolysis and thermogenesis through elevations in WAT-SNA and BAT-SNA, respectively, suppresses appetite by inhibiting the activities of the parasympathetic nerves innervating the gastrointestinal tract, including GVNA, and decreases the amount of abdominal fat and body weight via these changes.

PMID: 20580657 [PubMed - in process]

IGFBP-3: Binding Protein Turns on the Magical Fat Loss Properties of IGF-1

Posted by admin on 25th August , 2010

Special Binding protein extends life of IGF-1, Leads to Incredible Results

Science is finally catching up with what underground bodybuilders have known for years, but may not have known they knew it. IGF-1 is created in the liver when Growth Hormone is present. IGF-1 is responsible for many of the beneficial effects of Growth Hormone, and in some instances counteracts some of the negatives (High does of Growth Hormone cause insulin insensitivity because it makes cells completely reliant on their own triglycerides for energy). There has never been much debate about whether IGF-1 was beneficial to someone with a wasting disease or obesity. The trouble was, injected IGF never seemed to last long enough to gain any benefit from it. What Researchers have discovered however may surprise you. Read the rest of this entry »

Unique Chemical in Fruit Burns Fat

Posted by admin on 19th August , 2010

Citrus Auraptene, a unique compound found in citrus fruits, activates PPAR and Increases Adiponectin Expression In Vitro and In Vivo.

Fruit’s been given a really bad rap. I mean really bad. I hear it all the time. Oh, you should limit your amount of fruit during a diet. It’s going to wreck your diet. High Fructose Corn Syrup is nasty, just nasty. But that’s like saying sunshine is bad for you because it causes cancer. Fruit itself (and I’m not talking juices here) has so many unique and powerful fat burning, cancer killing and health promoting properties that you’d be a fool for not including them, even in fairly large amounts, in your diet if fat loss and overall health is your goal. Read the rest of this entry »

Obese People Burn More Fat

Posted by admin on 18th August , 2010

Fat People have Elevated Oxidation of Fatty Acids which Correlates to Metabolic Syndrome

Ok so that’s a bit of a misnomer but I wanted to catch your attention. The truth is people who are significantly overweight DO oxidize more fat in the liver on a regular basis compared to a healthier lean person. That’s because their system is broken. The liver shouldn’t be burning this fat, but it has to because the bloodstream is flooded with lipids (excess fat). The body’s cells have had enough fat and are sick of it so it gets dumped into the blood all the time in people who have metabolic syndrome. And because these people aren’t exercising the fat off or controlling their food intake those fat molecules have nowhere to go but the liver where this precious organ will try and deal with it by burning it up. But the amount of fat burning here is so insignificant that I wouldn’t even call it that except to catch your attention. Read the rest of this entry »

Mulberry Extract Aids in the War on Fat Loss

Posted by admin on 17th August , 2010

Korean treatment for diabetes and hyperlipidemia gains notable attention for its unique weight loss properties

A study released by the Diabetic Complications Research center reveals the mechanisms behind a promising extract that can be used to block absorption of fat in the intestines and can also increase the release of stored fat from fat cells. On top of that there is a significant degree of PDE inhibition which is the same kind of effect seen with Viagra or Cialis. The results were invitro (on a petri dish rather than in a living human, so that can sometimes throw the results off, but when we’re talking about lipolysis, which means the release of stored fat from fat cells to be used for energy, then this kind of result is usually enough for me. In otherwords this is a very specific cause and effect. The real trick is to see how this extract pans out in real world experience. It seems to have been used for hundreds of years in Traditional Korean Medicine for diabetes and hyperlipidemia (Fancy term for saying you have too much fat in your blood). Read the rest of this entry »