Effects of Eucommia Leaf Extracts on Fat Loss, Thermogenesis and Appetite
Posted by admin on 30th August , 2010Suppress Appetite and Increase Thermogenesis
A unique extract of Eucommia Ulmoides has been shown to increase thermogenesis and decrease parasympathetic nerves in the gut which leads to reduced appetite.
I normally wouldn’t go nuts about a hamster study, but this was pretty unique in that it wasn’t through the typical metabolic pathways most fat-reducers in rats usually produce results. Most rat and mice studies that show extremely promising fat-loss results are usually manipulating special metabolic parameters found only in mice and rats, not so much in humans. For instance brown adipose tissue is highly metabolically active. Anything that stimulates Brown Adipose Tissue is going to have a profound impact on fat loss and prevention of fat gain. Unfortunately, for humans, we don’t have but a tiny amount of brown adipose tissue so this phenomenon is almost entirely inconsequential to our own efforts.
But a few things made this study unique. One is that the thermogenesis was created by increasing nerve activity in BOTH white and brown adipose tissue (humans have plenty of white adipose tissue). Secondly there was an appetite suppression that came from parasympathetic nervous activity in the intestines. So this could be a good route of appetite suppression.
Eucommia Ulmoides, as I found out, has been used in traditional chinese medicine for years for lower back pain and to prevent miscarriage. If those effects seem odd it’s mostly because chinese medicine IS odd. I’m not here to argue its merits, but I find the whole TCM thing to be odd in general. Also, another interesting fact about Eucommia Ulmoides: Its leaves have latex inside them.
Neurosci Lett. 2010 Aug 2;479(3):181-6. Epub 2010 May 16.
Effects of Eucommia leaf extracts on autonomic nerves, body temperature, lipolysis, food intake, and body weight.
Horii Y, Tanida M, Shen J, Hirata T, Kawamura N, Wada A, Nagai K.
ANBAS Corporation, 4-12-17 Toyosaki, Kita-Ku, Osaka 531-0072, Japan. yhorii@anbas.co.jp
Abstract
Eucommia ulmoides Oliver leaf extracts (ELE) have been shown to exert a hypolipidemic effect in hamsters. Therefore, it was hypothesized that ELE might affect lipid metabolism via changes in autonomic nerve activities and causes changes in thermogenesis and body weight. We examined this hypothesis, and found that intraduodenal (ID) injection of ELE elevated epididymal white adipose tissue sympathetic nerve activity (WAT-SNA) and interscapular brown adipose tissue sympathetic nerve activity (BAT-SNA) in urethane-anesthetized rats and elevated the plasma concentration of free fatty acids (FFA) (a marker of lipolysis) and body temperature (BT) (a marker of thermogenesis) in conscious rats. Furthermore, it was observed that ID administration of ELE decreased gastric vagal nerve activity (GVNA) in urethane-anesthetized rats, and that ELE given as food reduced food intake, body and abdominal adipose tissue weights and decreased plasma triglyceride level. These findings suggest that ELE stimulates lipolysis and thermogenesis through elevations in WAT-SNA and BAT-SNA, respectively, suppresses appetite by inhibiting the activities of the parasympathetic nerves innervating the gastrointestinal tract, including GVNA, and decreases the amount of abdominal fat and body weight via these changes.
PMID: 20580657 [PubMed - in process]







